α2 –Plasmin Inhibitor
Circulates as single chain molecule consisting of 452 amino acids
50 mM Potassium phosphate, 7.5 mM KCl, 0.075 mM EDTA, pH 7.4
Concentration in plasma
Mode of action
Inhibits plasmin by forming an irreversible complex with the catalytic active site. Prevents the binding of plasmin to fibrin. Cross-linked by factor XIIIa to fibrin.
58,700 single-chain (determined from amino acid sequence and 14% carbohydrate) and 67,000 (determined by SDS-PAGE)