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Cell Line Modification (CRISPR/Cas9)

CRISPR Genome Editing for Cell Lines

CRISPR/Cas9 edited cell line models are great in vitro tools for studying gene function, designing disease models, for drug discovery and high throughput compound screening. At Applied StemCell, we have experience in editing > 100 distinct mammalian cell lines from different species, and have engineered more than 300 cell line models. We can genetically modify hard-to-transfect cells, blood lineage cells, slow growing cell lines, adherent/ suspension cells, stem cells and correct mutations in disease cell lines with a >97% success rate.



Full service cell line editing porfolio includes:

  • Choice of zygosity: homozygous and/or heterozygous clones
  • Choice of silent mutation at targeted site for point mutation insertion
  • Dedicated project management for detailed milestone and final reports


Some examples of cell line engineering projects include but are not limited to:

  • Knock-in/knockout modifications
  • Gene replacement
  • Gene overexpression
  • Conditional / inducible gene expression
  • Gene editing/ correction, including single base mutations
  • Gene tagging
  • Gene therapy
  • Promoter modifications
  • Gene fusion/ translocation
  • Removal of viral sequences
  • Stable cell lines / immortalization


Please contact us to discuss your project.