Induced pluripotent stem cells (iPSc)
Induced Pluripotent Stem Cells (iPSCs) are exceedingly popular because like embryonic stem cells (ESCs), they are pluripotent and can differentiate into all three germ layers with the potential to differentiate into all cell types within the body. And, unlike ESCs they are not encumbered with the ethical dispute associated with the sourcing of ESCs. The true potential of stem cell technology lies in the directed terminal differentiation of iPSCs into specific somatic cells. iPSC-derived cell lines provide an abundant and consistent source of material for studying the science behind human development, drug screening, personalized therapy in regenerative medicine, and disease modeling. The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage.
(an example of neuronal differentiation possibilities)