CellSystems

Human reconstructed skin has become increasingly important during the last few years in different fields

Chemical testing on reconstructed human epidermis already replaces animals for skin corrosion and skin irritation testing. These skin models are used for substance testing in the regulatory context of the cosmetics directive and under the REACH legislation. More complex skin models are established research tools for the cosmetics and pharmaceutical industry as well as for academia. Especially in this area, the diversity of skin models and applications is rapidly growing.

CellSystems offers the reconstructed human epidermis EST1000 (Epidermal Skin Test 1000).The reconstructed human epidermis consists of normal primary human epidermal keratinocytes. The cellular structure of EST1000 resembles that of the fully differentiated natural epidermis showing a base membrane, proliferating keratinocytes and a stratum corneum with an intact barrier function.

EST1000 is formally accepted for in vitro toxicity testing.