Growth Factors

Short info

CellSystems has a long experience in providing recombinant proteins for research applications. Based on extensive experiences in protein purification, the proteins are highly pure products with excellent biological activity.

Growth factors are soluble, small sized proteins that are secreted by cells

They are involved in a variety of cellular processes and act as signaling molecules between cells. They function to regulate cellular growth, division, proliferation and differentiation and influence the growth rate of some cancers. Growth factors bind to specific receptors on the surface of their responsive target cells.

Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related proteins. For example, the insulin family comprises somatemedins A and C, insulin, insulin-like growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGF), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologies have not been identified.

Growth factors often promote cell differentiation and maturation. For example, bone morphogenetic proteins (BMP) stimulate bone cell differentiation, while fibroblast growth factors (FGF) and vascular endothelial growth factors (VEGF) stimulate blood vessel differentiation.